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geant4/examples/advanced/dna/dsbandrepair/analysis/repairmodels/include/TLKModel.hh
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2024-12-06 11:11:40 +01:00

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/// \file TLKModel.hh
/// \brief Definition of the TLKModel class
#ifndef TLKMODEL_HH
#define TLKMODEL_HH
//#include <boost/numeric/odeint.hpp>
#include <vector>
#include <string>
class Damage;
class TLKModel
{
public:
/// \brief constructor
TLKModel(double pLambda1 =-1,double pLambda2=-1, double pBeta1=-1, double pBeta2=-1,double pEta=-1);
/// \brief destructor
~TLKModel() = default;
double GetLambda1(){return fLambda1;};
void SetLambda1(double pVal){fLambda1 = pVal;};
double GetLambda2(){return fLambda2;};
void SetLambda2(double pVal){fLambda2 = pVal;};
double GetBeta1(){return fBeta1;};
void SetBeta1(double pVal){fBeta1 = pVal;};
double GetBeta2(){return fBeta2;};
void SetBeta2(double pVal){fBeta2 = pVal;};
double GetEta(){return fEta;};
void SetEta(double pVal){fEta = pVal;};
double GetSingleDSBYield(){return fSingleDSBYield;};
void SetSingleDSBYield(double pVal){fSingleDSBYield = pVal;};
double GetComplexDSBYield(){return fComplexDSBYield;};
void SetComplexDSBYield(double pVal){fComplexDSBYield = pVal;};
unsigned int GetBpForDSB(){return fBpForDSB;};
void SetBpForDSB(unsigned int pVal){fBpForDSB = pVal;};
double GetStartTime(){return fStartTime;};
void SetStartTime(double pVal){fStartTime = pVal;};
double GetStopTime(){return fStopTime;};
void SetStopTime(double pVal){fStopTime = pVal;};
double GetStepTime(){return fStepTime;};
void SetStepTime(double pVal){fStepTime = pVal;};
// Compute damage inputs required by TLK model
void ComputeAndSetDamageInput(std::vector<Damage>);
// Compute SF for a given absorbed dose expressed in Gy
double ComputeSF(double pDose);
// Compute a SF Curve
void CalculateRepair(double pDoseMax, double pDeltaDose);
// Write output, dose expressed in Gy
void WriteOutput(std::string pFileName);
void SetDose(double d) {fDose = d;}
private:
std::vector<double> TLK_odes_system(double t,std::vector<double> y);
// TLK parameters
// simple DSB repair probability (h-1)
double fLambda1{0};
// complex DSB repair probability (h-1)
double fLambda2{0};
// simple DSB misrepair probability (h-1)
double fBeta1{0};
// complex DSB misrepair probability (h-1)
double fBeta2{0};
// binary misrepair probability (h-1)
double fEta{0};
// DSB Yields in Gy-1
double fSingleDSBYield{0};
double fComplexDSBYield{0};
// num of bp to consider a DSB for the MakeCluster function
// default value is 10
unsigned int fBpForDSB{10};
// Time for integration
double fStartTime{0};
double fStopTime{0};
double fStepTime{0};
// SF curve
std::vector<std::pair<double,double>> fSFCurve;
// store dose deposited in nucleus cell
double fDose{0};
};
#endif