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geant4/examples/advanced/dna/dsbandrepair/analysis/dnadamage/include/ScanDamage.hh
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2024-12-06 11:11:40 +01:00

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//
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// * *
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//
/// \file ScanDamage.hh
/// \brief Definition of the ScanDamage class
#ifndef ScanDamage_h
#define ScanDamage_h
#include <map>
#include <vector>
#include <string>
#include <tuple>
#include <set>
#include "Damage.hh"
#include <filesystem>
namespace fs = std::filesystem;
class TFile;
using ullint = unsigned long long int;
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struct VoxelData
{
VoxelData(int chromo, int domain, ullint firstBpCN)
{
fChromosome = chromo;
fDomain = domain;
fFirstBpCopyNum = firstBpCN;
}
~VoxelData() {}
int fChromosome{0};
int fDomain{0};
ullint fFirstBpCopyNum{0};
};
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typedef std::vector<std::vector<ullint> > Table;
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class Trier {
public:
bool operator()(const std::vector<ullint>& a, const std::vector<ullint>& b)
{
bool bb = false;
if(a[0] < b[0]) bb = true;
return bb;
}
};
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class ScanDamage
{
public:
ScanDamage();
~ScanDamage() = default;
std::map<unsigned int,std::map<unsigned int,std::vector<Damage> > > ExtractDamage();
void SetThresholdEnergy(double e) {fThresholdEnergy = e;}
void SetProbabilityForIndirectSBSelection(double p) {fProbabilityForIndirectSB = p;}
double GetThresholdEnergy() {return fThresholdEnergy;}
double GetProbabilityForIndirectSBSelection() {return fProbabilityForIndirectSB;}
std::map<int, Table> GetMergedSBData() {return fMergedTables;}
double GetEdepSumInNucleus() {return fEdepSumInNucleus;} //eV
double GetTotalNbBpPlacedInGeo() {return fTotalNbBpPlacedInGeo;}
double GetTotalNbHistonePlacedInGeo() {return fTotalNbHistonePlacedInGeo;}
double GetNucleusVolume() {return fNucleusVolume;}
double GetNucleusMassDensity() {return fNucleusMassDensity;}
double GetNucleusMass() {return fNucleusMass;}
std::map<int,ullint> GetChromosomeBpSizesMap() {return fChromosomeBpMap;}
void SkipScanningIndirectDamage() {fSkipScanningIndirectDamage = true;}
bool SkippedScanningIndirectDamage() {return fSkipScanningIndirectDamage;}
private:
void ScanDamageFromPhys();
void ScanDamageFromChem();
void RetrieveVoxelBp();
void FillVoxelData();
void AnaPhysRootFile(const std::string fileName);
void AnaChemRootFile(fs::directory_entry entry);
void AnaPhysRootTree1(TFile*);
void AnaPhysRootTree2(TFile*);
void SortPhysTableWithSelection();
void SortChemTableWithSelection();
void ReadCellandVoxelDefFilePaths();
void MergeDamageFromPhysChem();
std::tuple<unsigned int, unsigned int> GetEventNberAndVoxelNberFromChemRoot(const std::string fileNam);
double fThresholdEnergy{17.5};//eV
std::string fCellDefFilePath{""};
std::set<std::string> fVoxelDefFilesList;
std::map<std::string, int> fBpPerVoxel;
std::vector<VoxelData> fVoxels;
std::map<int, Table> fphysTables, fphysSlectedTables, fchemTables, fchemSlectedTables,fMergedTables;
std::map<unsigned int,std::map<unsigned int,std::vector<Damage> > > fDamage;
double fEdepSumInNucleus{0}; //eV
int corruptedFiles = 0;
double fTotalNbBpPlacedInGeo{0};
double fTotalNbHistonePlacedInGeo{0};
double fNucleusVolume{0};
double fNucleusMassDensity{0};
double fNucleusMass{0};
double fProbabilityForIndirectSB{0.4};
std::map<int,ullint> fChromosomeBpMap; //Store number of Bp in each Chomosomes;
bool fSkipScanningIndirectDamage{false};
};
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#endif