// // ******************************************************************** // * License and Disclaimer * // * * // * The Geant4 software is copyright of the Copyright Holders of * // * the Geant4 Collaboration. It is provided under the terms and * // * conditions of the Geant4 Software License, included in the file * // * LICENSE and available at http://cern.ch/geant4/license . These * // * include a list of copyright holders. * // * * // * Neither the authors of this software system, nor their employing * // * institutes,nor the agencies providing financial support for this * // * work make any representation or warranty, express or implied, * // * regarding this software system or assume any liability for its * // * use. Please see the license in the file LICENSE and URL above * // * for the full disclaimer and the limitation of liability. * // * * // * This code implementation is the result of the scientific and * // * technical work of the GEANT4 collaboration. * // * By using, copying, modifying or distributing the software (or * // * any work based on the software) you agree to acknowledge its * // * use in resulting scientific publications, and indicate your * // * acceptance of all terms of the Geant4 Software license. * // ******************************************************************** // // /// file: DamageModel.hh /// brief: Parameters related to the DNA Damage model #ifndef MOLECULAR_DAMAGE_MODEL #define MOLECULAR_DAMAGE_MODEL #include "DamageModelMessenger.hh" #include "G4Electron_aq.hh" #include "G4Hydrogen.hh" #include "G4MolecularConfiguration.hh" #include "G4OH.hh" #include "G4SystemOfUnits.hh" #include "Randomize.hh" #include "globals.hh" //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo...... class DamageModel { public: DamageModel(); virtual ~DamageModel() { delete fpDamageMessenger; }; // methods G4bool IsDirectStrandBreak(const G4double&) const; G4bool IsIndirectStrandDamage(const G4MolecularConfiguration*) const; G4bool IsIndirectBaseDamage(const G4MolecularConfiguration*) const; G4bool IsInducedStrandBreak(const G4MolecularConfiguration*) const; // setters void SetDirectDamageLower(G4double d) { fDirectDmgLower = d; if (fDirectDmgLower < fDirectDmgUpper) fDirectDmgUpper = fDirectDmgLower; }; void SetDirectDamageUpper(G4double d) { fDirectDmgUpper = d; if (fDirectDmgLower > fDirectDmgUpper) fDirectDmgLower = fDirectDmgUpper; }; // Indirect OH void SetIndirectOHStrandChance(G4double d) { CheckValidProbability("DamageStrandOH", d); fStrandOH = d; } void SetIndirectOHBaseChance(G4double d) { CheckValidProbability("DamageBaseOH", d); fBaseOH = d; } void SetInductionOHChance(G4double d) { CheckValidProbability("InductionOH", d); fInductionOH = d; }; // Indirect Eaq void SetIndirectEaqStrandChance(G4double d) { CheckValidProbability("DamageStrandEaq", d); fStrandEaq = d; } void SetIndirectEaqBaseChance(G4double d) { CheckValidProbability("DamageBaseEaq", d); fBaseEaq = d; } void SetInductionEaqChance(G4double d) { CheckValidProbability("InductionEaq", d); fInductionEaq = d; }; // Indirect H void SetIndirectHStrandChance(G4double d) { CheckValidProbability("DamageStrandH", d); fStrandH = d; } void SetIndirectHBaseChance(G4double d) { CheckValidProbability("DamageBaseH", d); fBaseH = d; } void SetInductionHChance(G4double d) { CheckValidProbability("InductionH", d); fInductionH = d; }; protected: static void CheckValidProbability(const G4String& str, G4double p); private: DamageModelMessenger* fpDamageMessenger; G4double fDirectDmgLower = 17.5 * eV, fDirectDmgUpper = 17.5 * eV; G4double fInductionOH = 0, fInductionEaq = 0, fInductionH = 0; G4double fStrandOH = 1.0, fStrandEaq = 1.0, fStrandH = 1.0; G4double fBaseOH = 1.0, fBaseEaq = 1.0, fBaseH = 1.0; const G4MoleculeDefinition* fOH = G4OH::Definition(); const G4MoleculeDefinition* fe_aq = G4Electron_aq::Definition(); const G4MoleculeDefinition* fH = G4Hydrogen::Definition(); }; //....oooOO0OOooo........oooOO0OOooo........oooOO0OOooo........oooOO0OOooo...... #endif // MOLECULAR_DAMAGE_MODEL